Deca 250

Description

Deca 250 is a prescription drug and is to be prescribed by a registered medical practitioner. You cannot administer these anabolic steroids on your own. Your doctor will determine the dosage and how long you should take them. As these anabolic steroids have a lot of complications, it is better to have a detailed discussion with your physician before undertaking Deca anabolic steroids.

Using these anabolic steroids may result in a few common side effects such as oedema (swelling of foot, ankles and feet), nausea, acne, fluid retention and breast enlargement. Immediately contact your doctor if any of these side effects (or any other) become severe.

Nandrolone Decanoate (Deca Durabolin), was first mentioned in the literature in 1960. A pharmaceutical company name Organon developed it for the first time and was later introduced for medical use under the brand name Deca Durabolin. In no time, Deca Durabolin became one of the most widely used AAS (Androgenic and Anabolic Steroid) in the world.

Nandrolone phenylpropionate was the first form of nandrolone to be introduced, which was later followed by nandrolone decanoate.

What is Deca

Nandrolone Decanoate or deca are anabolic steroids is commonly sold under the brand name of Deca Durabolin. It is an androgen and anabolic steroid medication (AAS), given as an injection into the muscle or fat once every one to four weeks.

Androgens are a group of hormones that play a major role in regulating the development and maintenance of masculine traits (like the growth of body hair, deepening of voice etc.,) and reproductive activities. The most common androgen is testosterone. Anabolic steroids are synthetic versions of androgens like testosterone. They are administered for a variety of purposes.

These type of anabolic steroids are usually used to rebuild tissues following a serious injury or a prolonged illness. Deca Durabolin may also be used to increase the lean body mass, in cases of negative nitrogen imbalance. But, they are more commonly used to treat older women (post-menopausal) suffering from osteoporosis, a condition where the bones become thin and brittle. It mimics the effects of the male sex hormone (testosterone).

History of Deca

Nandrolone Decanoate (Deca Durabolin), was first mentioned in the literature in 1960. A pharmaceutical company name Organon developed it for the first time and was later introduced for medical use under the brand name Deca Durabolin. In no time, Deca Durabolin became one of the most widely used AAS (Androgenic and Anabolic Steroid) in the world.

Nandrolone phenylpropionate was the first form of nandrolone to be introduced, which was later followed by nandrolone decanoate.

Other Names

This drug is most commonly addressed as Nandrolone decanoate, which is also its USAN (United States Adopted Name) and BAN (British Adopted Name). However, it has also been referred to as Nandrolone decylate.

Further, Nandrolone is being marketed under various brand names such as Deca Durabolin, Deca Durabol, Decaneurabol, Retabolil and Metadec among others.

How does Deca work?

Nandrolone decanoate works at the level of DNA and imitates the functions of the naturally occurring male sex hormone (testosterone) in the body. Nandrolone levels have a positive influence on the calcium metabolism of the body and increase the bone mass in cases of osteoporosis.

Chemical Structure

Nandrolone Decanoate, also known as Nandrolone 17β-decanoate is a derivative of testosterone and is a synthetic estrane steroid (or steroid esters). These are compounds that contain a steroid moiety, bearing a carboxylic acid ester group. It is an androgen ester. In particular, it is the C17β decylate (decanoate) ester of nandrolone (19-nortestosterone), which by itself is the 19-demethylated analogue of testosterone.

The chemical taxonomy of nandrolone decanoate can be given as follows:

Kingdom
Organic compounds

Super Class
Lipids and lipid-like molecules

Class
Steroids and steroid derivatives

Subclass
Steroid esters

Direct parent
Steroid esters

Alternative parents
Estrogens and derivatives / Delta-4-steroids / 3-oxo delta-4-steroids / Carboxylic acid esters / Monocarboxylic acids and derivatives / Cyclohexanones / Organic oxides / Hydrocarbon derivatives

Substituents
3-oxo delta-4-steroids, 3-oxosteroid, Carbonyl group, Aliphatic homopolycyclic compound, Carboxylic acid derivative, carboxylic acid ester, Cyclohexanone, Delta-4-steroid, Cyclic ketone, Estrane skeleton

Molecular framework
Aliphatic homopolycyclic compounds

External descriptors
Steroid ester

Absorption

A 50mg intramuscular dosage of nandrolone decanoate (Deca Durabolin) reaches a mean Cmax 2.14 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of about 400 h*ng/mL. A 100 mg intramuscular dosage of Deca Durabolin reaches a mean Cmax 4.26 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of around 862 h*ng/mL. A 150 mg intramuscular dosage of nandrolone decanoate reaches a mean Cmax 5.16 ng/mL, with a mean Tmax of approximately 72 hours, and a mean AUC of 1261 h*ng/mL.

Pharmacology

Pharmacodynamics (What does it do to your body)

Deca Durabolin is a prodrug (improves how the drug is absorbed) of nandrolone or is a nandrolone ester. As mentioned before, it is an androgenic and anabolic steroid or an agonist of AR, a biological target for androgens like testosterone and DHT. When compared to testosterone, nandrolone decanoate has enhanced several anabolic effects, while minimizing androgenic effects. For this reason, they are considered to be the most suitable AAS to be used in women and children.

In addition to its anabolic androgenic steroids activities, Deca Durabolin has minimal estrogenic activities (via its metabolite estradiol) and moderate progestogenic activity. Like any other AAS, nandrolone may also exhibit antigonadotropic effects. This may lead to several related side effect like gynecomastia and also the side effect of fluid retention. In order to avoid these side effects, you may need to stack your nandrolone with a few anti-estrogenic steroids.

Pharmacokinetics (How does your body react to the drug)

When Deca Durabolin or Deca anabolic steroids are given through an intramuscular injection into the body, it results in the formation of a long-lasting depot in the muscle. It is stored unchanged and is then slowly absorbed into the body. When it reaches the circulation, it gets converted into nandrolone, which is the active form of the drug.

The Deca Durabolin anabolic steroids level may reach a sharp spike in about 24 to 48 hours after the intramuscular injection, which is followed by a steady decline in the baseline levels in about two to three weeks. The bioavailability of the drug varies depending upon the site of injection, the highest is when injected into the gluteal muscle.

Deca Durabolin is swiftly hydrolyzed in the blood by esterases into nandrolone, with a terminal half-life of one hour or even less. The metabolism of nandrolone anabolic steroids usually occurs in the liver and is very much similar to the male sex hormone (testosterone).

The elimination half-life of Deca Durabolin (administered by intramuscular injection) is usually around 6 to 12 days. Nandrolone, along with its metabolites is excreted through urine in the form of conjugates.

Metabolism

Deca Durabolin is initially hydrolyzed to nandrolone, possibly by PDE7B. Nandrolone is further metabolized to the urinary metabolites namely 19-norandrosterone, 19-noretiocholanolone, and 19-norepiandrosterone. 19-norandrosterone is then 3-O-glucuronidated by UGT2B7, UGT 1A4, UGT2B4, UGT1A3, and UGT1A1. 19-noretiocholanolone is now 3-O-glucuronidated by UGT2B7, UGT2B4, UGT1A4, UGT1A10, UGT1A3, and UGT1A1.

Method of Elimination

Deca Durabolin is commonly eliminated in the form of metabolites through urine. However, data regarding its elimination through faeces is not readily available. Through studies made by observing cattle, it is found that around 30% of nandrolone is eliminated through faeces.

Half-life

Deca Durabolin is observed to have an absorption half-life of around 6 days and an elimination half-life of around 4.3 hours. Further studies have denoted that Deca Durabolin has a terminal half-life of about 7.1, 11.7 and 11.8 hours for the doses of 50 mg, 100 mg and 150 mg respectively.

What does it look like?

Deca Durabolin is a slightly yellow and oily solution used for injection. It commonly comes in a transparent 1 mL glass vial (its composition is around 50mg/ml), along with a needle.

Uses of Deca Durabolin

Medical Uses

Osteoporosis

Osteoporosis is a condition in which the bones of our body (especially those of the foot, ankles and knees) become very weak and brittle. They become so brittle that a small fall or even minor stressing like bending over or even coughing can cause the bones to fracture.

Osteoporosis related fractures most commonly occur in trivial bones such as the spine, hips or wrist. Osteoporosis generally occurs when the process of creation of new bones does not cope up with the loss of the existing old bones. Obviously, osteoporosis is more common among old people than young ones. Among them, it often occurs in women after menopause (the end of a woman’s menstrual cycle) and is known as post-menopausal osteoporosis.

Deca Durabolin is one of the most common drugs used in the treatment of osteoporosis in postmenopausal elderly women. It makes your bones strong and healthy, thereby reducing the risk of osteoporosis. It also aids in maintaining the bone density levels and thus protects it from breaking (fractures) easily.

Other Medical Uses

Apart from this, Deca Durabolin is also used in the treatment of anaemia of chronic kidney diseases, kidney failure, aplastic anaemia, inoperable breast cancer and for patients on long term corticosteroid therapy. It is also used as a therapy for people with conditions characterized by a negative nitrogen balance.

Deca Durabolin exhibits excellent results in preserving the lean mass (total weight of your body minus all the weight due to fat mass) of the body. Hence it is often used as an off-label drug for patients with HIV/AIDS and other wasting syndromes (conditions that cause the loss of more than 10 per cent of the person’s total weight).

In the past, Deca Durabolin is also known to be used for a variety of other conditions including post-operative and pre-operative use to increase lean mass, treating weight loss due to convalescence or diseases, severe trauma or certain cases of growth deficiency in children.

Nandrolone esters (Deca Durabolin esters) can also be used in androgen replacement therapy, to heal androgen deficiency in men. However, they are most commonly used as anabolic agents.

To summarize, Deca Durabolin has been used to treat the following medical uses :

• Osteoporosis in postmenopausal women
• Anaemia of chronic kidney diseases
• Kidney (Renal) failure
• Aplastic anaemia
• Inoperable breast cancer
• Negative nitrogen imbalance
• Preserve lean mass in HIV/AIDS patients and other wasting syndromes
• Maintain postoperative and preoperative lean mass
• Androgen replacement therapy

Non – medical uses

Apart from the wide medical uses, Deca Durabolin is popularly known for its performance and physique building purposes. For a long time, competitive athletes, bodybuilders and powerlifters have been using Deca Durabolin to enhance their physique and to gain improved performing skills.

It is generally consumed in 8-12 weeks of bulking cycles, along with a certain quantity of testosterone as a base. According to studies, when nandrolone is consumed solo (that is, without a base), it shuts down the normal production of testosterone in the body, by altering the blood and testis barrier components. In order to cope up with the reduced testosterone levels of the body, it is generally advised to stack your nandrolone intake with external testosterone as a base.

Deca Durabolin is one of the most common injectable AASs (Androgenic anabolic steroids) worldwide, used by athletes, bodybuilders and powerlifters. This is mainly because of the high anabolic to androgenic effect ratio of nandrolone and its weaker and milder side effects.

Nandrolone in bodybuilding

Nandrolone is widely known to increase the muscle mass of professional bodybuilders and powerlifters. It is a slow-acting anabolic steroid that promotes nitrogen retention in muscles and thereby leading to an increment in muscle size.

Nandrolone effects on athletes

Usually, the usage of anabolic steroids on athletes is not recommended. Existing objective pieces of evidence are conflicting as to whether the drug is actually improving athletic performance by increasing muscle strength.

Furthermore, the use of nandrolone anabolic steroids may result in unusual weight gains in part to fluid retention, which is one of the most common and hazardous side effects of steroid therapy.

Methods of Administration

The most preferred method of injecting Nandrolone is through an injection through the muscles. The bioavailability of Deca Durabolin decanoate highly depends upon the site of injection. While any intramuscular site is good, the bioavailability of the drug is found to be the highest when it is injected into the gluteal muscles.

Administration by subcutaneous injection

Although it is most commonly administered through intramuscular injections, it has been found to be similarly effective when it is administered by subcutaneous injection. However, this method is found to be much easier, more convenient and very less painful when compared to injecting it into the muscles.

Important Advice

This injection is generally administered by a registered medical practitioner, in a hospital or clinic setting. However, if you are advised to get this medicine at home, you will be taught how to prepare the injection and how to administer it. Act exactly according to the prescription and recommendation of your doctor. DO NOT take an extra dosage under any circumstances.

After using the medication, it is important to properly dispose of the injection in a special sharps container. Do not dispose of it in the trash can. If you do not have a special sharps container, consult your doctor or your pharmacist regarding its disposal.

Dosages

For general androgen replacement therapy in women, a dosage of about 25 to 50mg of Deca once every 6 to 12 weeks by getting injected inside the muscle by injection is commonly prescribed. In order to treat postmenopausal osteoporosis and inoperable breast cancer, a dosage of around 50 mg once every 2 to 4 weeks by intramuscular injection is usually prescribed.

To treat anaemia of chronic kidney disease in children aged 2 to 13 years, a dosage of 25 to 50mg once every 3 to 4 weeks by intramuscular injection is normally prescribed.

Side Effects

The side effects of Deca Durabolin primarily depends upon the dosage, the purpose of use, duration of usage and individual sensitivity. A variety of common, uncommon and rare side effects have been observed in people using this medication (at recommended dosages). The most common side effect of using Nandrolone in postmenopausal women (for the treatment of osteoporosis) is virilization. It may also cause redness and rashes at the site of injection.

Common Side Effects

Among the other observed side effects, the following are more common and can be expected at a greater rate

• Priapism – Priapism is a condition that causes a prolonged erection of the penis (without any sexual stimulation). This may even last for several hours (more than four hours) and is usually painful.
• Virilization – Virilization is the condition that causes the exhibition of masculine characteristics in women. Some of the properties exhibited are hoarseness of voice, acne, excessive facial/body hair growth, libido and even enlargement of the clitoris.
• Acne
• Breast Enlargement

Some of the other less common and infrequent side effects include :

• Altered interest in having sexual intercourse – The prolonged administration of nandrolone may sometimes result in a change in the sexual interests of the user.
• High Calcium content in the blood
• Enlargement of the prostate gland – Nandrolone can cause abnormal lumps or abnormal enlargement of the prostate gland and can even result in cancer under rare circumstances.
• Fluid retention – Fluid retention (or oedema) may usually occur when water or other fluids are not flushed away from the tissues. Nandrolone may trigger this condition.
• Leg cramps
• Allergic reactions (like skin rashes, hives or itching, swelling of the tongue, face and lips)
• Difficulty in sleeping
• Inhibition of spermatogenesis – Nandrolone may affect the process of creation and development of sperm cells in the testes. This causes a lower sperm count in the male reproductive system.
• Erectile dysfunction
• Lumps in the breasts
• Gynecomastia – It is the condition that causes the enlargement or swelling of the breast tissue in men. This disease usually occurs due to the imbalance in the estrogen and testosterone levels in the body. As mentioned before, Nandrolone induces a decrease in testosterone levels and thus results in an increased estrogen level, causing gynecomastia.
• Chills
• Dark urine
• Increased penis size in prepubertal boys
• Clitoral hypertrophy
• Testicular atrophy – A condition in which the male reproductive organ decreases in size and becomes less functional.
• Increased pubic hair growth
• Oligomenorrhea (Irregular menstruation)
• Amenorrhea (Absence of menstruation)
• Nausea
• Diarrhoea
• Elevated mood swings
• Bladder irritability and reduced urine flow
• Epididymitis – A condition that causes the enlargement of the epididymis
• Hyperlipidemia

Apart from these effects, Nandrolone may cause some more rare side effects such as :

• Liver Cancer
• Abdominal bloating
• Abnormal liver functioning
• Jaundice
• Peliosis hepatis – It is a condition that causes multiple, widespread, blood-filled cavities in the liver
• Oily skin
• Greasy hair
• Blood clots in veins
• Pruritus (Severe itchiness)
• Exanthema – Widespread rashes occurring throughout the body
• An increased bilirubin content in the blood

Averting Gynecomastia

As mentioned before, Deca Durabolin is an Androgenic and Anabolic Steroid (AAS). Further, it has minimal estrogenic activities (via its metabolite estradiol) and moderate progestogenic activities. Like any other AAS, nandrolone may also exhibit anti gonadotropic effects. That is, it suppresses or inhibits the effects of one or both of the gonadotropins, namely Follicle Stimulating Hormone (FSH) and the Luteinizing Hormone (LH).

This may lead to several side effects like fluid retention (a condition that prevents excess fluid from flushing out of tissues) and gynecomastia (a condition that causes the enlargement or swelling of the breast tissues in men, also known as “man boobs”).

Estrogen Imbalance

Obviously, they occur due to an imbalance in estrogen and testosterone levels (Higher estrogen and lesser testosterone levels). In order to avert the occurrence of these conditions, it is usually advised to stack your Deca Durabolin with other anti-estrogenic steroids.

Making use of anti-estrogenic steroids will reduce the estrogen content of your body. This brings a balance to the estrogen and testosterone levels, thereby aiding you to get rid of conditions such as gynecomastia and fluid retention.

Precautions

Deca Durabolin is an Androgenic and anabolic steroid medication and there are certain precautions to be considered before or during the administration of this medication. Initially, before you start taking this medication, have a detailed discussion with your doctor regarding your lifestyle, your profession, food habits, allergen information and your medical history.

Always Consult Your Doctor

If you prefer alcohol intake, kindly consult your doctor before you do so. Generally, there are no adverse effects of the drug due to alcohol intake, but it is not advised to take a lot of alcohol during your medication.

If you face a severe allergy to the medication or if you have an allergic history with Deca Durabolin, kindly stop your medication inform your doctor immediately.

Drug Intake During Pregnancy

Deca Durabolin is highly dangerous during pregnancy. It may cause adverse effects on the mother and the fetus and hence, intake of the drug during pregnancy is strictly not recommended. Please inform your doctor if you are pregnant, or if you think you are pregnant during the course of the medication.

Taking Deca Durabolin during breastfeeding is not yet studied extensively. However, it is advised to consult your doctor before undertaking the medication.

Deca Durabolin does not impair your vision or any other part of the brain that helps you to focus. So driving and operating any dangerous machinery may not be a problem during the course of the medication.

People with liver problems may experience a severe effect due to nandrolone. It affects your liver and it is advised to consult your doctor before you undertake your medication.

To summarize, it is advised to inform your doctor if you have recovered or have any one or more of the following conditions :

• Diabetes
• Breast cancer
• Heart disease
• Kidney disease
• Liver disease
• Prostate disease
• Porphyra (an inherited blood-related disorder)
• Previous allergic reaction to nandrolone
• Pregnant or trying to get pregnant
• Breastfeeding
• Children lesser than 3 years old
• Brain-related problems (like head injury and tumour)
• Mental/ mood disorders
• Breathing problems such as asthma
• Personal or family history of a substance use disorder (such as overuse or an addiction to a particular medicine), intestinal problems, pancreatic diseases.
• Epilepsy

Drug Interactions

Deca Durabolin may interact with other drugs in your body and cause some serious conditions. So it is advised to have a detailed discussion with your doctor regarding your other conditions, the drugs that you intake and your medical history.

Antiestrogens such as aromatase inhibitors (like anastrozole) and selective estrogen receptor modulators (like tamoxifen and raloxifene) can interfere with and inhibit the estrogenic effects of Deca Durabolin. Also, reductase inhibitors such as finasteride and dutasteride can inhibit the inactivation of nandrolone in so-called “androgenic tissues” like the skin, hair follicles, prostate gland and may therefore increase its androgenic side effects.

Past Medical History of Allergy

If you have any allergies or if you have an allergic history with Deca Durabolin, immediately stop the medication and consult your doctor as soon as possible. Deca Durabolin does not have any known records of interacting with food particles. However, it is better to consult your doctor if you have any queries regarding your food intake.

Some of the drugs that may interact with this medication and cause adverse effects may include :

• Leuprolide
• Diabetic medicines
• Prostate gland medicines (like dutasteride, saw palmetto, finasteride)
• Goserelin
• Warfarin
• Erythropoietin (used to treat anaemia)
• Carbamazepine

Note: DO NOT start, stop or alter any of your medications, while you are undertaking this medication without any consultation with your doctor.

Dietary Restrictions

If you have any allergies or if you have an allergic history with Deca Durabolin, immediately stop the medication and consult your doctor as soon as possible. Deca Durabolin does not have any known records of interacting with food particles. However, it is better to consult your doctor if you have any queries regarding your food intake.

What if you missed a dose?

If you forget to administer a dose of the injection, kindly take it as soon as you remember it. But if you remember it only after 24 hours of the time due, skip the missed dosage and consult your doctor on how to proceed with your dosage.

Note: Under any circumstances, DO NOT take an extra dose of the medication.

Overdosing

It is always advised to strictly adhere to the prescription of your doctor. DO NOT take an extra dosage of the medication under any circumstances. However, if you overdose anyway, consult your doctor immediately.

Patients facing a chronic overdose of anabolic steroids may experience several adverse effects including suppression of testosterone levels, leading to a decrease in spermatogenesis (resulting in a very low sperm count), shrinking of the testicles, erectile dysfunction and decreased libido in men. In women, it may cause suppression in the estrogen and progesterone levels, decreased ovulation, amenorrhea and clitoromegaly (unusual enlargement of the clitoris).

Overdosing patients may also exhibit neuropsychiatric, cardiovascular and hepatic adverse side effects. Mostly, alkylated anabolic steroids like nandrolone usually result in hepatic adverse effects.

If you notice anyone overdosing on Deca Durabolin and experiencing some severe side effects like having trouble breathing or passing out, kindly call 911 or contact the nearest local poison control centre.

Storage Instructions

Store this medicine in a cool, dry place and keep it out of reach from children and pets. This drug may cause serious problems if undertaken without the prescription of a registered medical practitioner. This medication can be abused. So, selling or giving away this medication is highly dangerous and is against the law. Usage of this medicine without a doctor’s prescription is illegal.

If you are using this medication at home, consult your doctor or pharmacist for more detailed storage instructions. Throw away the medicine once it has crossed its expiration date (mentioned on the label).

Summary

• You have been prescribed Deca Durabolin as your treatment procedure.
• Deca Durabolin is an Androgenic and Anabolic steroid (AAS), usually given as a treatment for osteoporosis in postmenopausal women.
• It is given as an intramuscular injection in the upper part of your arm or thighs by a registered medical practitioner.
• Kindly stick to the dosage prescribed by your doctor and never take an extra dosage.
• Stop your medication immediately and inform your doctor if you are allergic.
• Inform your doctor as soon as possible if you face any serious side effects or masculine characteristics (hoarse voice, acne, extensive hair growth, increased sex drive)
• Do not take this injection if you are already pregnant, breastfeeding or planning to conceive.
• Do not start, stop or alter any of your medications without consulting your doctor.